Compost Tea - The Tea Of Worms Explained

There is a certain kind of tea that no one should drink but is one of the most beneficial, nutrient filled solutions that has ever existed. It is called worm tea. What is worm tea? Here are a few tips on how you can create and use worm tea otherwise known as compost tea to enhance your organic gardening needs.

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Mass Customization in Pharma

The latest Knowledge@Wharton has an interview with Sidney Taurel, outgoing CEO of Eli Lilly.  In it he describes some rather dramatic and fundamental changes in the drug industry.

The new business model for companies like Eli Lilly will likely move away from production of such [Prozac, Cialis, Evista and Darvocet] "blockbuster" drugs and instead will focus on highly individualized solutions for patients, according to Taurel. It will emphasize therapies that work more often than not, as well as therapies that have a very clear benefit, thereby creating a more integrated system with greater economic and medical value. While some have dubbed the changes in health care "personalized medicine," Taurel prefers the term "tailored therapeutics."

Or perhaps a form of "pull medicine?"  Therapies designed for unique and even individual circumstances instead of pushing a solution to as wide a population as possible.  It's a significant, and risky, change to the traditional pharma business model.

The ultimate promise of tailored therapeutics is about "the individual patient, and we are prepared to stake our business on realizing that promise," Taurel said of Eli Lilly.

And as with manufacturing it comes down to maximizing value to the customer, where the customer is the end-user as well as the system that supports the process.

The practice of medicine remains too much of a trial-and-error process that has not maximized the efficacy of prescription therapies, which work about half the time for the most common diseases, he said. "When our industry is better able to target our products to the patients who will really benefit, then our value proposition will surely grow. When medicines are used more optimally to reduce the trial-and-error nature of health care, then fewer resources will be wasted and the cost of health care will be sustainable."

The analogy to lean manufacturing doesn't just describe the identification and delivery of therapies, but also the development process itself.

He used "biomarkers" -- or biological indicators -- as an example of one of the many modern advantages that will help drive the tailored therapeutics revolution. "Biomarkers are more pervasive and sophisticated than ever before, and they are coming into play in much earlier stages of drug development," Taurel said, noting that Eli Lilly now has biomarker strategies in place for nearly all molecules at the earliest clinical development stage.

Important benefits of biomarkers include the ability to weed out unpromising molecules early in the game, compress development times, run smaller and more focused trials and explore secondary indications earlier. "We hope that some of the beneficial effects of widespread biomarker indication will be shorter cycle times and lower costs in drug development," Taurel said.

Smaller and more focus trials that find problems and opportunities sooner, compressing development time.  Just as one piece flow is superior to how batch processing creates higher inventory cost as well as a higher risk and impact when problems are found.

Drug development is incredibly costly and risky.  I know one of my previous employers spent a couple hundred million dollars and ten years developing a new drug, just to have it almost immediately pulled from the market when three people died from a very rare interaction when combined with ten other drugs. The drug was effective, but public misperception forced the product to be removed from the market.  How would a more targeted and personalized development model survive?

Despite his optimism about the future of tailored therapeutics, Taurel acknowledged that some in the industry worry about the current business model being overturned -- specifically, that the lack of blockbuster drugs will reduce big pharma's ability to pay for the next generation of research and development.

Taurel said a more effective, targeted treatment has the potential to increase repeat prescriptions, as opposed to the current trend away from repeat prescriptions due to the lack of efficacy. Tailoring also bodes well for reducing costs and thus contributing to the bottom line. "The net result of sales can be quite virile. Instead of getting a relatively small slice of a large pie, the tailored model promises a larger share of a more segmented pie."

Doing that in a regulated market that requires huge sums to develop new products with increasingly long development times, which are even then subject to public and political fickleness, is a challenge.  To say the least.

What Makes Successful People Special?

Have you ever wondered what the successful people have that you are lacking? Is it money? Is it time? Do you really have to have money to make money or be successful? These are all questions I used to ask myself until I discovered what it really takes to make the grade.

Read Full Article Here: http://www.articlesbase.com/goal-setting-articles/what-makes-successful-people-special-368105.html

Cheap Trick [At Budokan: the Complete Concert]

Original Release: 1998
Disc one
1. "Hello There"
2. "Come On, Come On"
3. "ELO Kiddies"
4. "Speak Now Or Forever Hold Your Peace"
5. "Big Eyes"
6. "Lookout"
7. "Downed"
8. "Can't Hold On"
9. "Oh Caroline"
10. "Surrender"
11. "Auf Wiedersehen"
Disc two
1. "Need Your Love"
2. "High Roller"
3. "Southern Girls"
4. "I Want You To Want Me"
5. "California Man"
6. "Goodnight"
7. "Ain't That a Shame"
8. "Clock Strikes Ten"


dOwnlOad paRt 01, paRt 02
Password: www.skullbay.com

Budget Web Host Guidelines

Looking for web hosting for $10.00 per month? Well, budget web hosting is where it's at. Check out these guidelines for budget hosting.

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Answer to Your Needs With a Multifunctional Printer

A multifunctional printer is capable of doing various tasks, namely printing, photocopying and scanning. Learn more.

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Azoogle Seeks CPA Traction In Europe

Partnerships for New York-based performance ad network Azoogle in the United Kingdom and elsewhere in Europe may help drive acceptance of the cost per action model across the Continent.

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Comment on Keyword Research: How Many Searches Is Enough? by NBWeb.it - Nicola Boschetti

Hello Lynn, you wrote:

1) First, how new is your blog?
My blog has been launched on january 2008, but my domain is online since 2002. I had previous content, that i re-used for earliest blog posts.
Also, my website is already indexed in the SE (Google also) since i use a sitemap.xml

2) Make sure you have some good incoming links to your blog too.
I have about 800 links coming to my website, according to a backlink tool software.
I submitted my blog to many free directories, i am just working to get indexed in ODP (no luck so far).

3) The more social networking you do [..]
I am doing it… my blog is climbing Alexa rank with satisfaction (i started with 5millions and now i am 500.000) and also page visits are growing…

The problem is the keyword rank for single posts: i have tried to optimize posts with keywords density, ect ect but i got no clue why those post are not ranked…

What can i do next to improve single posts ranking?

Bingham Sweeps New England LMA Chapter Your Honor Awards

The Legal Marketing Association’s New England Chapter named the winners of its Sixth Annual Your Honor Awards at a gala event held at the Four Seasons Hotel in Boston.

The Your Honor Awards recognize law firms that have demonstrated excellence in marketing and business development during the preceding year. Twenty-two firms submitted 68 total entries across 13 possible categories.

“These awards demonstrate in technicolor the talent and breadth of the legal marketing industry in New England,” said Jeff Scalzi, Director of Marketing at Foley Hoag LLP and President of the LMA New England Chapter. “We are especially pleased this year to have entries from all six New England states, underscoring the continued growth of our profession in the region and the sophistication that law firms in New England are applying to innovative marketing and business development initiatives.”

The Sixth Annual LMA New England Your Honor Award winners were as follows:

Identity: First Place: Bingham McCutchen LLP for its brand relaunch; Second Place: Hamilton Smith Brook Reynolds, PC for its brand relaunch; Third Place: Foley Hoag LLP for its “Driving Business Advantage” brand launch.

Promotional Materials and Communications/Brochures and Collateral Materials: First Place: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo P.C. for its 2006 Mintz Levin Pro Bono Report; Second Place: Bingham McCutchen LLP for its “Who we are” booklet; Third Place: Foley Hoag LLP for its practice group brochures and eBook series.

Promotional Materials and Communications/External Communication: First Place: Hamilton Smith Brook Reynolds, PC for its “Freedom from Drab-Giving Thanks and Building Brand”; Second Place: Patridge Snow & Hahn LLP for its Annual Review; Third Place: Preti Flaherty LLP for its 2006 Annual Report.

Promotional Materials and Communications/Internal Communication: First Place: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo P.C. for its MintzKids Art Contest and Gallery Installation; Second Place: Foley Hoag LLP for its “Living Our Brand” internal brand launch campaign; Third Place: Robinson & Cole LLP, for its “The Source” internal business development and marketing newsletter.

Advertising: First Place: Bingham McCutchen LLP for its “Bear and Baby” ad; Second Place: Wiggin & Nourie, P.A. for its “Conflict Campaign”; Third Place: Goulston & Storrs for its “Donedeal Campaign”.

Web Sites: First Place: Choate Hall & Stewart, LLP for its new firm Web site; Second Place: Foley Hoag LLP for the new foleyhoag.com.

Media/Public Relations: First Place: Bingham McCutchen LLP for its “Firm-wide Media Program”.

Community Relations: First Place: Robinson & Cole LLP for its “e-Pal Program”; Second Place: Bingham McCutchen LLP for its “Say Yes Partnership”.

Sales/Business Development: First Place: Lahive & Cockfield, LLP and Seltzer Design for its “Lahive Litigation Tree Books”; Second Place: Wolf, Greenfield & Sacks, P.C. for its “Bio Royale” event.

Recruiting: First Place: Choate Hall & Stewart, LLP for its recruiting program; Second Place: Bingham McCutchen LLP for its recruiting “Web and Collateral”.

Gimme Award: First Place: Hamilton Smith Brook Reynolds, PC for its “Biotechnology Mega-Conference Kits”; Second Place: Wolf, Greenfield & Sacks, P.C. for its annual holiday card.

Best in Show/Less than 75 Attorneys: Hamilton Smith Brook Reynolds, PC for its “Making a Mega Presence at a Mega Conference”.

Best in Show/76-300 Attorneys: Robinson & Cole LLP for its “e-Pal Program”.

Best in Show/301+ Attorneys: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo P.C. for its “MintzKids Art Contest and Gallery Installation”.

A panel of six judges composed of marketing executives from professional services industries and B2B-focused companies selected the award winners, including the “Best in Show” to extraordinary entries.  The award ceremony was The evening was sponsored by The Wall Street Journal, and account manager John Jardin served as the master of ceremonies.

With more than 225 members, the New England chapter is one of the largest in the country. Through monthly educationalprogramming, network opportunities, a growing annual conference, and other value-added member services, the New England Chapter brings law firm marketing professionals, service providers and lawyers from across the six New England states together to promote the profession. For additional information about the Legal Marketing Association’s New England chapter, please visit its Web site at www.lmanewengland.org.

Turning Old Photos into a Business

BangorNews:

If you have old photographs lying around your home just waiting to be organized, then Rhon Bell might be your man. Bell, 22, a fifth-year business and finance student at the University of Maine, officially opened PhotoScan from his Orchard Trails apartment in Orono on Monday. He aims to “digitize memories, one shoebox at a time,” by scanning collections of old photos, retouching them and saving them onto a CD for future use.

Bell got the idea for his business last fall and went to UM's Student Innovation Center, now called the Foster Student Innovation Center. With help from some of the eight-member staff of students and business experts, he created and distributed locally a survey to gauge demand for his service. When 75 percent of respondents said they would be interested, he decided to move forward and the center helped him write a business plan and legally register his business.

The 5,000-square-foot center, which offers business and project development services to students of all disciplines, is hopping with networking events, workshops, seminars and meetings between students and businesses, financiers, advisers and professors.

Photo via leavyphotography

The Age of the Electronic Keyboard

The electronic keyboard can be any one of many things - organ, piano, synthesizer or sampler. Learn more.

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Online Degrees - 5 Simple Tips To Help You Get Financial Aid For An Online Degree

If you're looking for financial aid to help fund your online degree program then this article can help you understand what is available.

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